GTC Biotherapeutics (GTC) has demonstrated consistent expression levels for fusion molecules including immunoglobulin (Ig) fusions in the milk of transgenic animals in the 2 - 6 gram per liter range. Production of fusions require stable integration of two (or more) gene constructs, simultaneous expression of each protein and proper assembly into tetrameric protein complexes.
GTC has successfully produced more than seven Ig fusion proteins in the milk of transgenic animals. We have been successful in expressing Ig fusions containing antibody molecules linked to enzymes for in vivo targeting, single chain antibodies, hybrid molecules containing ligands attached to an immunoglobulin-like scaffold and fusions of receptors to antibody fragments (i.e. PRO542 for Progenics Pharmaceuticals). Publications by GTC which discuss Immunoglobulin fusions (Newton et al, 1999 and Pollock et al, 1999) can be ordered from our publications section.
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